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From Medellin:

Buses leave every hour from the North Bus Terminal in Medellin (terminal del norte). The bus schedule is from 5 a.m. to 5:30 p.m. The journey takes 3 hours and has a cost of 20.000 COP. When you arrive to the town square of San Rafael, there are motocarros (three-wheel-cabs which cost 14 mil COP and can take up to 3 passengers) and motocabs (6.000 per person) available. Ask them to take you to Ritmo del Rio en la Vereda el Macanal. the ride takes about 15 minutes.

From Guatape:

Buses are passing by on the mainstrip of Guatape every hour. The bus schedule is from 7 a.m. to 7 p.m. The journey takes 1 hour and has a cost of 8.000 COP. When you arrive to the town square of San Rafael, there are motocarros(three-wheel-cabs which cost 14 mil COP) and motocabs (6.000 per person) available. the ride takes about 15 minutes.

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